VARIABLE DOMAIN ENGINEERING

• HUMANIZATION

• CDR ULTRA-HUMANIZATION

- Paratope mapping

-  ABS germlining

• LIABILITY ENGINEERING

- Developability 

- PTMs

- Hydrophobicity

- Charge patches

- Polyspecificity

- Immunogenicity

Fc ENGINEERING

• EFFECTOR FUNCTION

- ADCC, ADCP, CDC

- Effector function null

- FcγR, C1q silent 

- Isotype reformating

- Mutations

- Aglycosylation

- Effector function enhanced

- Mutations

- Afucosylation

- Effector function optimized

- Act. vs inhib. FcγRs

• HALF-LIFE EXTENSION / OPTIMIZATION

- YTE, CS mutations

- FcRn silencing mutations

FORMATS

• MONOCLONAL ANTIBODIES

• BI/MULTI-SPECIFICS

• T/NK CELL ENGAGERS

• NANOBODIES, VHHs

• scFvs, CARs

• ADCs

• OTHER PROTEIN BASED THERAPEUTICS

BIOLOGICAL FUNCTION

• ANTAGONISTS

• AGONISTS

• CELL DEPLETING

• PAYLOAD DELIVERY

• DEGRADERS

• RADIOLIGANDS

• PROTEIN REPLACEMENT