Specializing in strategy and execution, we can help operationalize every step of the way – from reagent generation, early research and screening, hit-to-lead, lead optimization, and selecting development candidates for IND-enabling activities and beyond
We have vast expertise with CRO management to enable antibody discovery, engineering and optimization utilizing a variety of platforms. We can help you develop and execute your discovery campaign to leverage cutting-edge technologies, including in vivo immunizations (hybridoma & B cell cloning), in vitro display (phage & yeast), molecular modeling & rational design
Having 20+ years of immunology research experience, we can also guide you through cell-based assay development to demonstrate efficacy and MOA, in vivo POC studies, and clinical indication selection.
Our expertise can also help you coordinate your IND-enabling activities - CMC, PK/PD, toxicology/safety studies, ADA/nAb/anti-Id assays & reagents - as well as translational strategy and biomarker readouts.
DISCOVERY
Hit-to-lead
Molecular format selection
Immunization, selection & screening strategy
Discovery campaign outsourcing
Assay development
Reagent generation
Protein production
HTS hits analysis and triaging
Hit identification & validation
Orthogonal profiling
Preliminary developability profiling
LEAD OPTIMIZATION
Biotherapeutic engineering
Affinity maturation
Antibody & protein engineering
Fc engineering & effector function optimization
Selectivity & cross-reactivity
Biosphysical properties & developability optimization
Manufacturability
Immunogenicity
Structure-based design
PK/PD optimization
CANDIDATE SELECTION
IND-enabling activities
Off-target profiling
Complete developability profiling
CMC readiness
PK/PD & toxicology support
ADA & nAb assay, anti-Id reagent generation
CDMO cell line & process development, phase I supply
Translational strategy & biomarkers integration
Intellectual property filing support